SARS-CoV-2 infection and effects of age, sex, comorbidity, and vaccination among older individuals: A national cohort study.

Mai A MahmoudHoussein H AyoubPeter CoylePatrick TangMohammad R HasanHadi M YassineAsmaa A Al ThaniZaina Al-KanaaniEinas Al-KuwariAndrew JeremijenkoAnvar Hassan KaleeckalAli Nizar LatifRiyazuddin Mohammad ShaikHanan F Abdul-RahimGheyath K NasrallahMohamed Ghaith Al-KuwariAdeel A ButtHamad Eid Al-RomaihiMohamed H Al-ThaniAbdullatif Al-KhalRoberto BertolliniLaith Jamal Abu-Raddad Hiam Chemaitelly

Published in: Influenza and other respiratory viruses (2023)

Incidence of severe COVID-19 in older adults followed a dynamic pattern shaped by infection incidence, variant severity, and population immunity. Age, sex, and coexisting conditions were strong determinants of infection severity. Vaccine protection against severe outcomes showed a dose-response relationship, highlighting the importance of booster vaccination for older adults.

Keyphrases

physical activity
risk factors
sars cov
early onset
respiratory syndrome coronavirus
drug induced
adipose tissue
metabolic syndrome
insulin resistance
weight loss