Recycling of SLC38A1 to the plasma membrane by DSCR3 promotes acquired temozolomide resistance in glioblastoma.

Rui LinYimin XuSidi XieYunxiao ZhangHai WangGuo-Zhong YiGuanglong HuangBowen NiHaimin SongZiyu WangSong-Tao QiYa-Wei Liu

Published in: Journal of neuro-oncology (2022)

DSCR3 is a crucial regulator of acquired TMZ resistance in MGMT-deficient GBM. The DSCR3-dependent recycling of SLC38A1 maintains its abundance on plasma membrane, leading to tumor progression and acquired TMZ resistance in MGMT-deficient GBM.

Keyphrases

microbial community
long non coding rna
life cycle