Neutrophil extracellular traps (NETs) are web-like structures composed of cytoplasmic contents, DNA chromatin and various granular proteins released by neutrophils in response to viruses, bacteria, immune complexes and cytokines. Studies have shown that NETs can promote the occurrence, development and metastasis of tumors. In this paper, the mechanism underlying the formation and degradation of NETs and the malignant biological behaviors of NETs, such as the promotion of tumor cell proliferation, epithelial mesenchymal transition, extracellular matrix remodeling, angiogenesis, immune evasion and tumor-related thrombosis, are described in detail. NETs are being increasingly studied as therapeutic targets for tumors. We have summarized strategies for targeting NETs or interfering with NET-cancer cell interactions and explored the potential application value of NETs as biomarkers in cancer diagnosis and treatment, as well as the relationship between NETs and therapeutic resistance.
Keyphrases
- extracellular matrix
- cell proliferation
- epithelial mesenchymal transition
- papillary thyroid
- risk assessment
- endothelial cells
- squamous cell carcinoma
- signaling pathway
- drug delivery
- cell cycle
- dna methylation
- transforming growth factor
- oxidative stress
- young adults
- cancer therapy
- cell free
- climate change
- pi k akt
- childhood cancer
- wound healing
- nucleic acid