The Genetic Architecture of Parkinson Disease in Spain: Characterizing Population-Specific Risk, Differential Haplotype Structures, and Providing Etiologic Insight.
Sara Bandres-CigaSarah AhmedMarya S SabirCornelis BlauwendraatAstrid D Adarmes-GómezInmaculada Bernal-BernalMarta Bonilla-ToribioDolores Buiza-RuedaFátima CarrilloMario Carrión-ClaroPilar Gómez-GarreSilvia JesúsMiguel A Labrador-EspinosaDaniel MaciasCarlota Méndez-Del-BarrioTeresa Periñán-TocinoCristina Tejera-ParradoLaura Vargas-GonzálezMonica Diez-FairenIgnacio AlvarezJuan Pablo TartariMariateresa BuongiornoMiquel AguilarAna GorostidiJesús Alberto BergarecheElisabet MondragonAna Vinagre-AragonIoana CroitoruJavier Ruiz-MartínezOriol Dols-IcardoJaime KulisevskyJuan Marín-LahozJavier PagonabarragaBerta Pascual-SedanoMario EzquerraAna CámaraYaroslau ComptaManel FernándezRubén Fernández-SantiagoEsteban MuñozEduard TolosaFrancesc ValldeoriolaIsabel Gonzalez-AramburuAntonio Sanchez RodriguezMaría SierraManuel Menéndez-GonzálezMarta BlazquezCiara GarciaEsther Suarez-San MartinPedro García-RuizJuan Carlos Martínez-CastrilloLydia VelaClara RuzFrancisco Javier BarreroFrancisco Escamilla-SevillaAdolfo Mínguez-CastellanosDebora CerdanCesar TaberneroMaria Jose Gomez HerediaFrancisco Perez ErrazquinManolo Romero-AcebalCici FelizJose Luis Lopez-SendonMarina MataIrene Martínez TorresJonggeol Jeffrey KimClifton L Dalgardnull nullJanet BrooksSara Saez-AtienzarJ Raphael GibbsRafael JordaJuan A BotiaLuis Bonet-PonceKaren E MorrisonCarl ClarkeManuela TanHuw MorrisConnor EdsallDena HernandezJavier Simon-SanchezMike A NallsSonja W ScholzAdriano Jimenez-EscrigJacinto DuarteFrancisco VivesRaquel DuranJanet HoenickaVictoria AlvarezJon InfanteMaria José MartiJordi ClarimónAdolfo López de MunainPau PastorPablo MirAndrew Singletonnull nullPublished in: Movement disorders : official journal of the Movement Disorder Society (2019)
Our data demonstrate the utility of the Spanish risk haplotype substructure for future fine-mapping efforts, showing how leveraging unique and diverse population histories can benefit genetic studies of complex diseases. The present study points to PARK2 as a major hallmark of PD etiology in Spain. © 2019 International Parkinson and Movement Disorder Society.