Large-Scale Whole-Genome Analysis of HTLV-1-Associated Myelopathy Identified Hereditary Spastic Paraplegias.

Naoki TakaoNaoko YagishitaNatsumi ArayaSatoko ArataniJunji YamauchiKatsunori TakahashiYasuo KunitomoTomoo SatoMasahiro NakamoriYosuke KawaiYosuke OmaeKatsushi TokunagaFumihiko MatsudaSatomi MitsuhashiYoshihisa Yamano

Published in: Neurology. Genetics (2024)

Genetic analysis is useful for the differentiation of hereditary spastic paraplegia patients from HTLV-1-associated myelopathy patients, especially for the patients with low levels of CSF inflammatory markers. Here we report the presence of hereditary spinal cord diseases in patients diagnosed with HTLV-1-associated myelopathy and provides evidence that genetic analysis would be helpful in the diagnostic workflow.

Keyphrases

spinal cord
end stage renal disease
ejection fraction
chronic kidney disease
newly diagnosed
spinal cord injury
patient reported outcomes
neuropathic pain
electronic health record
upper limb
botulinum toxin