Azithromycin Augments Bacterial Uptake and Anti-Inflammatory Macrophage Polarization in Cystic Fibrosis.
Abdullah A TariqueNeeraj TuladharDean KelkNelufa BegumRichard M LucasLin LuoJennifer L StowClaire E WainwrightScott Cameron BellPeter D SlyEmmanuelle FantinoPublished in: Cells (2024)
This study highlights the cellular functions and molecular targets of AZM which may involve an improved uptake of both Gram-positive and Gram-negative bacteria, restored anti-inflammatory macrophage polarization in CF. This may in turn shape the reduced lung inflammation observed in clinical trials. In addition, we confirmed the role of ERK1/2 activation for bacterial uptake.