Antibodies toward Na + ,HCO 3 - -cotransporter NBCn1/SLC4A7 block net acid extrusion and cause pH-dependent growth inhibition and apoptosis in breast cancer.

Trine V AxelsenClaus OlesenDanish KhanAli MohammadiElena V BouzinovaChristine J F NielsenMarco MeleKatrine R HauerslevHelene L PedersenEva BallingPernille VahlTrine TrammPeer M ChristiansenDonna M B Boedtkjer

Published in: British journal of cancer (2024)

Inhibitory anti-NBCn1 antibodies block net acid extrusion in human breast cancer tissue, particularly from patients with disseminated disease, and pH-dependently limit triple-negative breast cancer growth.

Keyphrases

endothelial cells
oxidative stress
endoplasmic reticulum stress
cell death
induced pluripotent stem cells
young adults
cell proliferation
childhood cancer