The severity of behavioural symptoms in FTD is linked to the loss of GABRQ-expressing VENs and pyramidal neurons.
Priya Gami-PatelMarta ScarioniFemke H BouwmanBaayla Dimitri Catharina BoonJohn Cornelis van SwietenNetherlands Brain BankAnnemieke J M RozemullerAugust B SmitYolande A L PijnenburgJeroen J M HoozemansAnke A DijkstraPublished in: Neuropathology and applied neurobiology (2022)
We show that in FTD, a loss of VENs together with GABRQ-expressing pyramidal neurons is associated with TDP43 and FUS pathology. No significant loss was found in donors with FTLD-tau pathology; however, this could be due to the specific MAPT mutation studied and small sporadic FTLD-tau sample size. Overall, we show the GABRQ-expressing population correlates with behavioural changes and suggest they are key in modulating behaviour in FTD.