Macrophages modulate fibrosis during newt lens regeneration.
Georgios TsissiosAnthony SalleseJ Raul Perez-EstradaJared A TangemanWeihao ChenByran SmuckerSophia C RatvaskyErika Grajales-EsquivelArielle MartinezKimberly J VisserAlberto Joven ArausHui WangAndrás SimonMaximina H YunKatia Del Rio-TsonisPublished in: Stem cell research & therapy (2024)
Together, our findings highlight the importance of macrophages for facilitating a pro-regenerative environment in the newt eye by regulating fibrotic responses, modulating the overall inflammatory landscape, and maintaining the proper balance of early proliferation and late apoptosis of the iPECs.