Serial markers of coagulation and inflammation and the occurrence of clinical pulmonary thromboembolism in mechanically ventilated patients with SARS-CoV-2 infection; the prospective Maastricht intensive care COVID cohort.
Mark M G MulderLloyd BrandtsRenée A G BrüggemannMarcel KoelmannAlexander S StrengRenske H OlieHester A GietemaHenri M H SpronkIwan C C van der HorstJan-Willem E M SelsJoachim E WildbergerJustin G L M LuermansRonny M SchnabelHugo Ten CateYvonne M C HenskensBas C T van BusselPublished in: Thrombosis journal (2021)
Lower average concentrations of fibrinogen over time were associated with the presence of clinical pulmonary thromboembolism in patients at the Intensive Care, whereas D-dimer, CRP and ferritin were not. Lower concentrations over time may indicate the consumption of fibrinogen related to thrombus formation in the pulmonary vessels.