Asperbenzophenone A and Versicolamide C, New Fungal Metabolites from the Soft Coral Derived Aspergillus sp. SCSIO 41036.
Jieyi LongXiaoyan PangXiuping LinShengrong LiaoXuefeng ZhouJunfeng WangBin YangYong-Hong LiuPublished in: Chemistry & biodiversity (2022)
Two new compounds, asperbenzophenone A (1) and versicolamide C (5), together with fifteen known compounds were isolated from a soft coral derived fungus Aspergillus sp. SCSIO 41036. Their structures were elucidated by spectroscopic methods, ECD analysis, and by a comparison with data from the literature. In bioassay, compound 8 showed significant inhibitory activity against lipopolysaccharide-inducted nitric oxide (NO) in RAW264.7 cells at the concentration of 10 μM. Additionally, the anti-acetylcholinesterase activity assay showed that 14 exhibited weak inhibition with an IC 50 value of 157.8 μM.
Keyphrases
- nitric oxide
- induced apoptosis
- cell wall
- cell cycle arrest
- molecular docking
- ms ms
- inflammatory response
- high throughput
- electronic health record
- high resolution
- toll like receptor
- hydrogen peroxide
- nitric oxide synthase
- endoplasmic reticulum stress
- cell death
- machine learning
- signaling pathway
- mass spectrometry
- oxidative stress
- cell proliferation
- data analysis
- artificial intelligence