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Genome-wide effects of social status on DNA methylation in the brain of a cichlid fish, Astatotilapia burtoni.

Austin T HilliardDan XieZhihai MaMichael P SnyderRussell D Fernald
Published in: BMC genomics (2019)
Our results revealed genome-wide effects of A. burtoni social status on DNA methylation in the brain and strongly suggest a role for methylation in modulating plasticity across multiple biological levels. They also suggest many novel hypotheses to address in mechanistic follow-up studies, and will be a rich resource for identifying the relationships between behavioral, neural, and transcriptional plasticity in the context of social status.
Keyphrases
  • genome wide
  • dna methylation
  • gene expression
  • healthcare
  • mental health
  • copy number
  • white matter
  • resting state
  • signaling pathway
  • cerebral ischemia
  • heat shock