Fe(III)-Triggered Radical Arylation of Arene Moieties from Cyclopropanols to Construct Dibenzocyclohepta/octanones: Synthesis of N -Acetylcolchinol- O -methyl ether.

Tricyclic 6-7-6 and 6-8-6 carbon ring systems are present in numerous biologically active natural molecules. However, simple and efficient synthetic approaches to these scaffolds remain challenging. Herein, we report a versatile strategy for constructing these ring systems via Fe(NO 3 ) 3 -triggered radical arylation of arenes starting from cyclopropanols. This synthetic utility has been demonstrated in the synthesis of the natural product N -acetylcolchinol- O -methyl ether.