Invasive Lactococcus lactis producing mycobacterial Hsp65 ameliorates intestinal inflammation in acute TNBS-induced colitis in mice by increasing the levels of the cytokine IL-10 and secretory IgA.
Vanessa P da CunhaTatiane M PreisserMariana P SantanaDenise C CaraVanessa B PereiraAnderson MiyoshiPublished in: Journal of applied microbiology (2020)
This study, which used L. lactis for the production and delivery of Hsp65, has scientific relevance because it shows the efficacy of this new strategy based on therapeutic protein delivery into mammalian enterocytes.