A Novel Liposomal S-Propargyl-Cysteine: A Sustained Release of Hydrogen Sulfide Reducing Myocardial Fibrosis via TGF-β1/Smad Pathway.

Ba Hieu TranYing YuLingling ChangBo TanWanwan JiaYing XiongTao DaiRui ZhongWeiping ZhangVan Minh LePeter RoseZhijun WangYicheng MaoQiu-Yan Zhang

Published in: International journal of nanomedicine (2019)

The liposomal formulations of ZYZ-802 have enhanced pharmacokinetic and pharmacological properties in vivo. This work is the first report to describe the development of liposomal formulations to improve the sustained release of H2S within tissues.

Keyphrases

transforming growth factor
epithelial mesenchymal transition
gene expression
left ventricular
living cells
atrial fibrillation