Inadequate Lopinavir Concentrations With Modified 8-hourly Lopinavir/Ritonavir 4:1 Dosing During Rifampicin-based Tuberculosis Treatment in Children Living With HIV.

Chishala Chabala Anna TurkovaMonica KapasaKristen LeBeauChimuka H TemboKevin ZimbaLubbe WeisnerKhozya Davie Zyambo Louise Choo Chalilwe ChunguJoyce LunguVeronica Mulenga Angela Crook Diana M Gibb Helen M McIlleronnull null

Published in: The Pediatric infectious disease journal (2023)

Modified 8-hourly dosing of lopinavir/ritonavir failed to achieve adequate lopinavir concentrations with concurrent antituberculosis treatment. The subtherapeutic lopinavir exposures on standard dosing after antituberculosis treatment are of concern and requires further evaluation.

Keyphrases

mycobacterium tuberculosis
emergency department
radiation therapy
replacement therapy
rectal cancer
smoking cessation