Captive ERVWE1 triggers impairment of 5-HT neuronal plasticity in the first-episode schizophrenia by post-transcriptional activation of HTR1B in ALKBH5-m6A dependent epigenetic mechanisms.

Xiulin WuLianzhong LiuXing XueXuhang LiKexin ZhaoJiahang ZhangWenshi LiWei YaoShuang DingChen JiaFan Zhu

Published in: Cell & bioscience (2023)

Overall, HTR1B, Arc, and ALKBH5 levels were increased in schizophrenia and positively associated with ERVWE1. Moreover, ALKBH5 was a novel risk gene for schizophrenia. ERVWE1 impaired 5-HT neuronal plasticity in ALKBH5-m6A dependent mechanism by the HTR1B-ERK-ELK1-Arc pathway, which may be an important contributor to aberrant synaptic plasticity in schizophrenia.

Keyphrases

bipolar disorder
gene expression
dna methylation
signaling pathway
cell proliferation
transcription factor