Increased extracellular vesicle miRNA-466 family in the bronchoalveolar lavage fluid as a precipitating factor of ARDS.

Sotaro ShikanoYasuhiro GonShuichiro MaruokaTetsuo ShimizuYutaka KozuYuko IidaMari HikichiMai TakahashiShinichi OkamotoKota TsuyaAsami FukudaKenji MizumuraShu Hashimoto

Published in: BMC pulmonary medicine (2019)

These findings imply that miRNA-466 family molecules are secreted via EVs into the airways in an ARDS model, and this exacerbates inflammation through the NLRP3 inflammasome. Our results suggest that the NLRP3 inflammasome pathway, regulated by extracellular vesicle miRNA, could act as a therapeutic target for ARDS.

Keyphrases

nlrp inflammasome
acute respiratory distress syndrome
extracorporeal membrane oxygenation
mechanical ventilation
oxidative stress
cystic fibrosis
intensive care unit