Nrf2 promotes esophageal squamous cell carcinoma (ESCC) resistance to radiotherapy through the CaMKIIα-associated activation of autophagy.
Di XiaXiao-Ran ZhangYan-Li MaZhi-Jun ZhaoRen ZhaoYan-Yang WangPublished in: Cell & bioscience (2020)
Our study reveals that Nrf2 promotes the radiation resistance of ESCC by targeting CaMKIIα and subsequently activating autophagy, which is characterized by the suppression of phosphorylated mTOR and p62, activation of Beclin 1, and transformation of LC3-I to LC3-II.