The R1441C-LRRK2 mutation induces myeloid immune cell exhaustion in an age- and sex-dependent manner.

Rebecca L WallingsKaren McFarlandHannah A StaleyNoelle NeighbargerSusen SchaakeNorbert BrüggemannSimone ZittelTatiana UsnichChristine KleinEsther M SammlerMalú Gámez Tansey

Published in: bioRxiv : the preprint server for biology (2023)

mutation causes an age-acquired immune cell exhaustion in macrophages in sex-dependent manner.

Keyphrases

bone marrow
dendritic cells
acute myeloid leukemia