Break-through bleeding in relation to pharmacokinetics of Factor VIII in paediatric patients with severe haemophilia A.
Xiaoling ChengP LiZhenping ChenN ZhangY ZhenL ZhaoX WangR WuPublished in: Haemophilia : the official journal of the World Federation of Hemophilia (2017)
t1/2 was an important indicator to prevent bleeding in severe HA; the frequency of bleeding will be reduced with the increased of t1/2 of FVIII. The data also demonstrates that increasing the time with a FVIII<1 IU/dL is associated with an increased rate of bleeding during prophylaxis.