Exploring the expression and potential function of follicle stimulating hormone receptor in extragonadal cells related to abdominal aortic aneurysm.

V N TedjawirjaA MieremetK B RomboutsC YapA E NeeleBernd H Northoff Hung-Jen ChenM VosD KlaverK K YeungR BalmV de Waard

Published in: PloS one (2023)

Despite previous reports, we did not detect FSHR gene expression in various extragonadal cell types, except in occasional female AAA-SMCs. No clear effect on cell activation was observed upon FSH stimulation in any cell type. Our data suggest that a direct effect of FSH in AAA-related extragonadal cells is unlikely to influence AAA.

Keyphrases

induced apoptosis
gene expression
abdominal aortic aneurysm
cell cycle arrest
single cell
dna methylation
cell death
cell therapy
oxidative stress
endoplasmic reticulum stress
stem cells
cell proliferation
risk assessment
long non coding rna
climate change