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Niche matters: The comparison between bone marrow stem cells and endometrial stem cells and stromal fibroblasts reveal distinct migration and cytokine profiles in response to inflammatory stimulus.

Masuma KhatunAnna SorjamaaMarika KangasniemiMeeri SutinenTuula SaloAnnikki LiakkaPetri LehenkariJuha S TapanainenOlli VuolteenahoJoseph C ChenSiri LehtonenTerhi T Piltonen
Published in: PloS one (2017)
Our results highlight that similar to bmMSCs, the eMSCs possess high migration activity while the differentiation process towards stromal fibroblasts seemed to result in loss of stem cell surface markers, minimal migration activity and a subtler cytokine profile likely contributing to normal endometrial function.
Keyphrases
  • stem cells
  • bone marrow
  • cell surface
  • mesenchymal stem cells
  • extracellular matrix
  • endometrial cancer
  • cell therapy
  • single cell