The role of GLP-1 in the postprandial effects of acarbose in type 2 diabetes.

Niels B DalsgaardLærke S GasbjergLaura S HansenNina L HansenSigne StensenBolette HartmannJens F RehfeldJens J HolstTina VilsbøllFilip K Krag Knop

Published in: European journal of endocrinology (2021)

We confirm that acarbose treatment stimulates postprandial GLP-1 secretion in patients with type 2 diabetes. Using exendin(9-39)NH2, we did not see an impact of acarbose-induced GLP-1 secretion on absolute measures of postprandial glucose tolerance, but relatively, the effect of exendin(9-39)NH2 was most pronounced during acarbose treatment.

Keyphrases

type diabetes
blood glucose
cardiovascular disease
room temperature
combination therapy
glycemic control
adipose tissue
skeletal muscle
replacement therapy