Intratumoural production of TNFα by bacteria mediates cancer therapy.
Carola MurphyElizabeth RettedalPanos LehouritisCiarán DevoyMark TangneyPublished in: PloS one (2017)
Mice remained healthy throughout experiments. This study indicates the therapeutic efficacy and safety of TNFα expressing bacteria in vivo, highlighting the potential of non-pathogenic bacteria as a platform for restricting the activity of highly potent cancer agents to tumours.