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The role of serum amyloid A1 in the adipogenic differentiation of human adipose-derived stem cells basing on single-cell RNA sequencing analysis.

Rongmei QuKai HeYuchao YangTingyu FanBing SunAsmat Ullah KhanWenhua HuangJun OuyangXinghua PanJingxing Dai
Published in: Stem cell research & therapy (2022)
Our results also indicated that our adipogenic induction was successful, and there was great heterogeneity in the adipogenic differentiation of ASCs. SAA1 with the regulation of inflammatory response were involved in adipogenesis of ASCs based on single-cell RNA sequencing analysis. The data obtained will help to elucidate the intrinsic mechanism of heterogeneity in the differentiation process of stem cells, thus, guiding the regulation of self-renewal and differentiation of adult stem cells.
Keyphrases
  • single cell
  • stem cells
  • rna seq
  • inflammatory response
  • high throughput
  • endothelial cells
  • type diabetes
  • cell therapy
  • machine learning
  • metabolic syndrome
  • adipose tissue
  • skeletal muscle
  • deep learning
  • data analysis