Acquired resistance to irradiation or docetaxel is not associated with cross-resistance to cisplatin in prostate cancer cell lines.

Lukas DonixHolger H H ErbClaudia PeitzschAnna DubrovskaManuel PfeiferChristian ThomasSusanne FuesselKati Erdmann

Published in: Journal of cancer research and clinical oncology (2022)

Like patients, different mCRPC cell lines exhibit significant variability regarding CDDP tolerance. The presented in vitro data suggest that previous radiation treatment may be associated with a moderate sensitization to CDDP in an isogenic and age-matched setting. Therefore, previous radiotherapy or docetaxel chemotherapy might be no contraindication against initiation of platinum chemotherapy in selected mCRPC patients.

Keyphrases

prostate cancer
end stage renal disease
locally advanced
chronic kidney disease
ejection fraction
newly diagnosed
squamous cell carcinoma
peritoneal dialysis
early stage
radiation induced
radiation therapy
machine learning
artificial intelligence
big data
smoking cessation