Vitamin C sensitizes BRAFV600E thyroid cancer to PLX4032 via inhibiting the feedback activation of MAPK/ERK signal by PLX4032.

Xi SuPeng LiBin HanHao JiaQingzhuang LiangHaichao WangMengwei GuJiaxuan CaiShaolei LiYaqi ZhouXin YiWei Wei

Published in: Journal of experimental & clinical cancer research : CR (2021)

Vitamin C promotes the antitumor effect of PLX4032 in BRAFMT thyroid cancer cell and xenografts model via relieving the feedback activation of MAPK/ERK as well as PI3K/AKT pathway. PLX4032/Vitamin C combination may be a potential therapeutic approach to treat BRAFMT thyroid cancer.

Keyphrases

signaling pathway
pi k akt
induced apoptosis
cell proliferation
endoplasmic reticulum stress