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Differential impact of PI3K/AKT/mTOR signaling on tumor initiation and progression in animal models of prostate cancer.

Shuaibin WangChao ZhangZhifang XuMichael H ChenHaiyan YuLizhong WangRunhua Liu
Published in: The Prostate (2022)
Our results for genetically engineered mouse models suggest a differential role of the PI3K/AKT/mTOR signaling nodes in prostate cancer initiation and progression, but the underlying molecular mechanisms remain unaddressed.
Keyphrases
  • prostate cancer
  • radical prostatectomy
  • mouse model
  • sentinel lymph node
  • radiation therapy
  • neoadjuvant chemotherapy
  • rectal cancer