miR-21-5p promotes NASH-related hepatocarcinogenesis.
Pedro M RodriguesMarta B AfonsoAndré L SimãoTawhidul IslamMaria M GasparColm J O'RourkeMonika LewinskaJesper B AndersenEnara ArretxeCristina AlonsoÁlvaro Santos-LasoLaura Izquierdo-SanchezRaúl Jimenez-AgüeroEmma EizaguirreLuis BujandaMaria J ParejaCarina Prip-BuusJesus Maria BanalesCecília Maria Pereira RodriguesRui E CastroPublished in: Liver international : official journal of the International Association for the Study of the Liver (2023)
Hsa-miR-21-5p is a key inducer of whole-spectrum NAFLD progression, from simple steatosis to NASH and NASH-associated carcinogenesis. The inhibition of hsa-miR-21-5p, leading to a pro-metabolic profile, might constitute an appealing therapeutic approach to ameliorate NASH and prevent progression towards HCC.