Estrogen Receptor β Activation Mitigates Colitis-associated Intestinal Fibrosis via Inhibition of TGF-β/Smad and TLR4/MyD88/NF-κB Signaling Pathways.

Fangmei LingYi-Dong ChenJunrong LiMingyang XuGengqing SongLei TuHuan WangShuang LiLiangru Zhu

Published in: Inflammatory bowel diseases (2024)

Estrogen receptor β may regulate intestinal fibrosis through modulation of the TGF-β/Smad and TLR4/MyD88/NF-κB signaling pathways. Targeting ERβ activation could be a promising therapeutic strategy for treating intestinal fibrosis.

Keyphrases

estrogen receptor
signaling pathway
transforming growth factor
toll like receptor
epithelial mesenchymal transition
pi k akt
nuclear factor
inflammatory response
lps induced
immune response
induced apoptosis
oxidative stress
liver fibrosis