Monocarboxylate transporter 4 inhibition potentiates hepatocellular carcinoma immunotherapy through enhancing T cell infiltration and immune attack.
Yuan FangWeiren LiuZheng TangXiang JiYufu ZhouShushu SongMengxin TianChenyang TaoRun HuangGuiqi ZhuXifei JiangJun GaoWeifeng QuHan WangPeiyun ZhouXiaoling WuLei JinHaixiang SunZhenbin DingYuanfei PengShimin ZhaoJian ZhouJia FanWei XuYing-Hong ShiPublished in: Hepatology (Baltimore, Md.) (2022)
Our results revealed that lactate exportation by MCT4 has a tumor-intrinsic function in generating an immunosuppressive HCC environment and demonstrated the proof of the concept of targeting MCT4 in tailoring HCC immunotherapeutic approaches.
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