Transcriptomic analysis reveals the role of SIX1 in mouse cranial neural crest patterning and bone development.
Aparna BaxiKaryn JourdeuilTimothy C CoxDavid E ClouthierAndre L P TavaresPublished in: Developmental dynamics : an official publication of the American Association of Anatomists (2023)
Our results clarify the mechanisms by which SIX1 regulates the development of NC-derived craniofacial elements that are altered in SIX1-associated disorders. In addition, this work identifies novel genes that could be causative to this birth defect and establishes a link between SIX1 and WNT signaling during patterning of NC cells.