Genetic strategy to decrease complement activation with adenoviral therapies.

Christopher M GentileAnton V BorovjaginJillian R RichterAditi H JaniHongju WuKurt R ZinnJason M Warram

Published in: PloS one (2019)

Displaying a complement-inhibiting peptide on the Ad5 capsid surface by genetic modification of the hexon protein could be a suitable strategy for reducing Ad5 liver tropism (Ad5 sequestration by liver), which may be applicable to other gene therapy vectors with natural liver tropism.

Keyphrases

gene therapy
genome wide
signaling pathway
gene expression
dna methylation
small molecule
amino acid