TET-mediated DNA hydroxymethylation is negatively influenced by the PARP-dependent PARylation.
Anja TolićMirunalini RavichandranJovana RajićMarija ĐorđevićMiloš ĐorđevićSvetlana DinićNevena GrdovićJelena Arambašić JovanovićMirjana MihailovićNataša NestorovićTomasz P JurkowskiAleksandra S UskokovićMelita S VidakovićPublished in: Epigenetics & chromatin (2022)
According to our findings, PARP inhibition can positively influence TET activity and therefore affect global levels of DNA methylation and hydroxymethylation. This gives a strong rationale for future examination of PARP inhibitors' potential use in the therapy of cancers characterised by loss of 5-hydroxymethylcytosine.