lncRNA-PLACT1 sustains activation of NF-κB pathway through a positive feedback loop with IκBα/E2F1 axis in pancreatic cancer.
Xiaofan RenChanghao ChenYuming LuoMingyang LiuYuting LiShangyou ZhengHuilin YeZhiqiang FuMin LiZhihua LiRufu ChenPublished in: Molecular cancer (2020)
Our findings suggest that PLACT1 provides a novel epigenetic mechanism involved in constitutive activation of NF-κB signaling pathway and may represent a new therapeutic target of PDAC.