Early, empiric high-dose leucovorin rescue in lymphoma patients treated with sequential doses of high-dose methotrexate.
Jason N BarretoKristen T PetersonErin F BarretoKristin C MaraRoss A DierkhisingNelson LeungThomas E WitzigCarrie A ThompsonPublished in: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer (2021)
Sequential HDMTX doses are associated with a significant incidence of elevated MTX levels and AKI during lymphoma management. HDLV rescue prescribed during subsequent MTX doses in patients with a previously elevated level was not associated with improved safety outcomes. The optimal supportive care strategy following HDMTX administration requires further investigation.