Metformin reduces the risk of poor treatment outcomes among individuals with rifampicin-resistant tuberculosis and type-2 diabetes mellitus.

Argita D SalindriMariam GujabidzeMaia KipianiNino LomtadzeNestani TukvadzeZaza AvalianiHenry M BlumbergHardy KornfeldRussell R KempkerMatthew J Magee

Published in: medRxiv : the preprint server for health sciences (2024)

We conducted a retrospective cohort study among individuals with rifampicin-resistant tuberculosis and diabetes to determine the association between metformin use and tuberculosis treatment outcomes. We found that individuals with metformin use had a significantly lower risk of poor tuberculosis treatment outcomes (adjusted RR=0.25, 95%CI 0.06 - 0.95) compared to those without.

Keyphrases

mycobacterium tuberculosis
pulmonary tuberculosis
hiv aids
cardiovascular disease
adverse drug
emergency department
metabolic syndrome
hepatitis c virus
electronic health record