The interplay of type I and type II interferons in murine autoimmune cholangitis as a basis for sex-biased autoimmunity.

Heekyong R BaeDeborah L HodgeGuo-Xiang YangPatrick S C LeungSathi Babu ChodisettiJulio C ValenciaMichael SanfordJohn M FenimoreZiaur S M RahmanKoichi TsuneyamaGary L NormanM Eric GershwinHoward A Young

Published in: Hepatology (Baltimore, Md.) (2018)

Our data implicate type I IFN signaling as a necessary component of the sex bias of this murine model of autoimmune cholangitis. Importantly these data suggest that drugs that target the type I IFN signaling pathway would have potential benefit in the earlier stages of PBC. (Hepatology 2018;67:1408-1419).

Keyphrases

signaling pathway
electronic health record
dendritic cells
immune response
multiple sclerosis
big data
drug induced
machine learning
induced apoptosis