High serum uric acid levels are protective against cognitive impairment in amyotrophic lateral sclerosis.

Barbara IazzolinoMaurizio GrassanoCristina MogliaAntonio CanosaUmberto ManeraRosario VastaSara CabrasStefano CallegaroEnrico MatteoniFrancesca Di PedeFrancesca PalumboGabriele MoraAndrea CalvoAdriano Chio

Published in: Journal of neurology (2023)

We found that in ALS lower UA serum levels are correlated with reduced frequency of co-morbid FTD. Patients with intermediate cognitive impairment showed UA levels similar to ALS-CN but higher than ALS-FTD, implying that higher UA levels can prevent or delay cognitive function deterioration.

Keyphrases

cognitive impairment
uric acid
amyotrophic lateral sclerosis
metabolic syndrome
bariatric surgery
squamous cell carcinoma
weight loss