PI3Kα targeting, nipping pancreatic cancer evolution in the bud.

Glancis Luzeena Raja ArulMartin E Fernandez-Zapico

Published in: EMBO molecular medicine (2021)

Thibault et al (2021) elucidate key signalling events mediating metastatic evolution in pancreatic ductal adenocarcinoma (PDAC) by demonstrating a role of PI3Kα in the regulation of macro-metastatic disease and a corresponding pro-tumoural immune response supporting disease progression.

Keyphrases

immune response
squamous cell carcinoma
small cell lung cancer
cancer therapy
dendritic cells
toll like receptor
inflammatory response