Specificity of translocator protein-targeted positron emission tomography in inflammatory joint disease.
Yusuf HeloGraham E SearleFederica BorgheseSonya AbrahamAzeem SaleemPublished in: EJNMMI research (2020)
[11C]PBR28 is TSPO-specific radioligand in IJD patients. Simplified PET protocols with static PET acquisition can be used in the management and evaluation of novel therapeutics that target TSPO overexpressing cells.
Keyphrases
- binding protein
- positron emission tomography
- pet imaging
- computed tomography
- pet ct
- end stage renal disease
- chronic kidney disease
- induced apoptosis
- ejection fraction
- newly diagnosed
- oxidative stress
- small molecule
- peritoneal dialysis
- cell cycle arrest
- cell proliferation
- signaling pathway
- cell death
- structural basis
- protein protein