Helicobacter pylori Status May Differentiate Two Distinct Pathways of Gastric Adenocarcinoma Carcinogenesis.
Martin TobiDouglas WeinsteinMijin KimJames HatfieldPaula SochackiEdi LeviTeisa AnMerlin HamreVasundhara ToliaSuzanne FligielRama MarepallyJason HallmanBharati BapatMei YuanBenita L McVickerSteven GallingerPublished in: Current oncology (Toronto, Ont.) (2023)
The HP+ sporadic GC group appears to proceed through a sequence of HP infection, IM and atrophy before cancer supervenes, and the HP- phenotype appear to omit this sequence. The familial cases may represent a subset with both features, but the natural history strongly resembles that of the HP- group. Two different paths of carcinogenesis may exist locally for sporadic GC. The InImS may also be implicated in prognosis. Identifying these patients will allow for treatment stratification and early diagnosis to improve GC survival.
Keyphrases
- helicobacter pylori
- end stage renal disease
- helicobacter pylori infection
- late onset
- ejection fraction
- chronic kidney disease
- newly diagnosed
- gas chromatography
- squamous cell carcinoma
- prognostic factors
- amyotrophic lateral sclerosis
- early onset
- patient reported outcomes
- mass spectrometry
- radiation therapy
- combination therapy
- locally advanced
- free survival
- smoking cessation
- replacement therapy