Coupling of PARP1-mediated chromatin structural changes to transcriptional RNA polymerase II elongation and cotranscriptional splicing.

Elena A MatveevaQamar M H Al-TinawiEric C RouchkaYvonne N Fondufe-Mittendorf

Published in: Epigenetics & chromatin (2019)

These studies suggest a context-specific effect of PARP1-chromatin binding on RNA polymerase movement and provide a platform to delineate PARP1's role in RNA biogenesis and processing.

Keyphrases

dna damage
dna repair
gene expression
transcription factor
oxidative stress
genome wide
high throughput
dna binding
room temperature
ionic liquid
electron transfer