Detection of Sars-Cov-2 antigens in thyroid gland showing histopathological features of subacute thyroiditis.
Hrvoje JakovacAntun FerenčićChristophe StembergerBojana Mohar VitezićDražen CuculićPublished in: European thyroid journal (2022)
The clinical and laboratory findings of subacute thyroiditis have been repeatedly reported as being associated with acute Sars-Cov-2 infection and post-COVID-19 syndrome. The exact mechanisms and histopathological correlations underlying thyroid involvement remained unresolved, but current insights suggest either direct viral damage, systemic inflammatory reaction, or an autoimmune response as possible noxious effectors. Here we present findings of immunohistochemical/immunofluorescence detection of Sars-Cov-2 viral proteins (spike/S and nucleocapside proteins) in relation to histoarchitectonic changes of autoptic thyroid tissue obtained from patient who deceased from COVID-19.
Keyphrases
- sars cov
- respiratory syndrome coronavirus
- case report
- loop mediated isothermal amplification
- oxidative stress
- drug induced
- real time pcr
- liver failure
- multiple sclerosis
- respiratory failure
- immune response
- density functional theory
- kidney transplantation
- sensitive detection
- molecular dynamics
- acute respiratory distress syndrome