Liquid Biopsy for Invasive Mold Infections in Hematopoietic Cell Transplant Recipients With Pneumonia Through Next-Generation Sequencing of Microbial Cell-Free DNA in Plasma.

Joshua A HillSudeb C DalaiDavid K HongAsim A AhmedCarine HoDesiree HollemonLily BlairJoyce MaaloufJacob Keane-CandibTerry Stevens-AyersMichael BoeckhTimothy A BlauwkampCynthia E Fisher

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2022)

Noninvasive mcfDNA-Seq had moderate sensitivity and high specificity, NPV, and PPV for pulmonary IMI after HCT, particularly for non-Aspergillus species.

Keyphrases

single cell
rna seq
pulmonary hypertension
bone marrow
microbial community
genome wide
copy number
high intensity
ultrasound guided
fine needle aspiration
cell wall
intensive care unit
dna methylation
mesenchymal stem cells
community acquired pneumonia
circulating tumor