Senolytic Combination Treatment Is More Potent Than Single Drugs in Reducing Inflammatory and Senescence Burden in Cells from Painful Degenerating IVDs.

Matthew MannarinoOliver Wu-MartinezKai ShengLi LiRodrigo Navarro-RamirezPeter JarzemJean A OuelletHosni Cherif Lisbet Haglund

Published in: Biomolecules (2023)

Combining o-Vanillin and RG-7112 greatly enhanced the effect of either senolytic alone. Together, these results support the potential of senolytics as a promising treatment for IVD-related low back pain.

Keyphrases

endothelial cells
risk factors
combination therapy
replacement therapy
smoking cessation