Proximity-driven bioorthogonal reactions via DNA circuits enable the accurate aptasensing of non-nucleic acid targets.
Su-Jing ZhaoHaiyu GuoZhen-Kun WuJian-Hui JiangPublished in: Chemical communications (Cambridge, England) (2022)
Tetrazine-mediated bioorthogonal reactions were rationally coupled with DNA cascade circuits to enable proximal decaging, which allowed the construction of a fluorogenic aptasensor for the accurate and amplified sensing of non-nucleic acid targets in live cells.