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Proximity-driven bioorthogonal reactions via DNA circuits enable the accurate aptasensing of non-nucleic acid targets.

Su-Jing ZhaoHaiyu GuoZhen-Kun WuJian-Hui Jiang
Published in: Chemical communications (Cambridge, England) (2022)
Tetrazine-mediated bioorthogonal reactions were rationally coupled with DNA cascade circuits to enable proximal decaging, which allowed the construction of a fluorogenic aptasensor for the accurate and amplified sensing of non-nucleic acid targets in live cells.
Keyphrases
  • nucleic acid
  • induced apoptosis
  • high resolution
  • cell cycle arrest
  • oxidative stress
  • cell death
  • single molecule
  • mass spectrometry