Proximity-driven bioorthogonal reactions via DNA circuits enable the accurate aptasensing of non-nucleic acid targets.

Su-Jing ZhaoHaiyu GuoZhen-Kun Wu Jian-Hui Jiang

Published in: Chemical communications (Cambridge, England) (2022)

Tetrazine-mediated bioorthogonal reactions were rationally coupled with DNA cascade circuits to enable proximal decaging, which allowed the construction of a fluorogenic aptasensor for the accurate and amplified sensing of non-nucleic acid targets in live cells.

Keyphrases

nucleic acid
induced apoptosis
high resolution
cell cycle arrest
oxidative stress
cell death
single molecule
mass spectrometry