The COX2 Effector Microsomal PGE2 Synthase 1 is a Regulator of Immunosuppression in Cutaneous Melanoma.

Sun-Hee KimJason RoszikSung-Nam ChoDai OgataDenái R MiltonWeiyi PengDavid G MenterSuhendan EkmekciogluElizabeth A Grimm

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)

Our results are the first to illustrate a potential role for mPGES1 inhibition in melanoma immune evasion and selective targeting in supporting the durability of response to PD-1 checkpoint immunotherapy. More research effort in this drug development space is needed to validate the use of mPGES1 inhibitors as safe treatment options.

Keyphrases

skin cancer
dna damage
cell cycle
regulatory t cells
cancer therapy
basal cell carcinoma
cell proliferation
drug delivery