Early, robust mucosal secretory IgA but not IgG response to SARS-CoV-2 spike in oral fluid is associated with faster viral clearance and COVID-19 symptom resolution.

Nora Pisanic Annukka A R Antar Marissa K Hetrich Zoe O DemkoXueyan ZhangKristoffer SpicerKate L KruczynskiBarbara DetrickWilliam ClarkeMaria Deloria KnollDavid L ThomasFatimah S DawoodVic Veguilla Ruth A Karron Yukari C Manabe Christopher D Heaney

Published in: The Journal of infectious diseases (2024)

Robust mucosal SIgA early post infection appears to support faster clearance of SARS-CoV-2 and recovery from COVID-19 symptoms. This research underscores the importance of harmonizing mucosal immune response assays to evaluate new mucosal vaccines.

Keyphrases

sars cov
ulcerative colitis
respiratory syndrome coronavirus
immune response
coronavirus disease
depressive symptoms
toll like receptor
physical activity
inflammatory response